Severe Cutaneous Adverse Reaction to Piperacillin-Tazobactam: A Case of Stevens-Johnson Syndrome.

Stevens-Johnson syndrome (SJS) is a rare condition characterized by an exaggerated immune system response to triggers such as infections or drugs. It is characterized by blistering and exfoliation of the skin and affects mucosal surfaces, including the eyes, buccal cavity, and genitals. We report a case of a 50-year-old male who developed symptoms of SJS following a recent hospital admission for acute appendicitis The patient presented with fever, erythematous patches on the palms, abdomen, groins, and oral mucosa. The onset of symptoms occurred approximately four days after discharge from the hospital, where the patient had received treatment including intravenous antibiotics (Piperacillin-Tazobactam), ranitidine, tramadol, and intravenous fluids. He was diagnosed with SJS based on clinical and histopathological findings and was treated with supportive care and corticosteroids. He recovered after one week of hospitalization. This case highlights the importance of recognizing the potential risk of developing SJS following drug administration and the need for prompt identification and management of the condition to prevent complications and improve patient outcomes.

An Unusual Case of Allergic Contact Dermatitis Due to Nepafenac Eye Drop.

Eyelid dermatitis is a common occurrence in several skin disorders, including seborrheic dermatitis, atopic dermatitis and psoriasis. However, it is primarily associated with allergic contact dermatitis (ACD). Here, we present a case of 51-year-old woman who developed pruritic erythema of the eyelids after using 0.1% Nepafenac eye drops. Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) commonly prescribed as eye drops for various inflammatory eye conditions. Instances of ACD caused by Nepafenac eye drops are exceedingly rare based on available case reports. Nevertheless, it is important to consider ACD as a potential cause when a patient with eyelid dermatitis has a history of Nepafenac eye drop usage. The Naranjo algorithm, which was used for assessing causality, determined the likelihood of this case being a possible instance of ACD due to Nepafenac (Naranjo score=3).